Learn how significant physical changes can occur in tablets when distributed in low barrier or multi-use containers in as little as 30 days.
April 4/26/2016, 2:15 PM - 3:00 PM, Javits Conventions Center, Meeting Room 1
Technical presentation: Session: Study of the Effect of Primary Packaging on the Physical Degradation of Metformin, Lisinopril, & Simvastatin Solid Doses During Patient Usage When Stored at Different Temperature and Humidity Conditions
The presentation will review the adverse effects daily exposure to oxygen and moisture may have on non-coated tablets of Simvastatin (for high cholesterol), Lisinopril (for high blood pressure/hypertension) and Metformin (for Type 2 Diabetes) when contained in multi-dose containers, such as traditional amber pharmacy vials and plastic bottles requiring repeated opening and closing, or low-barrier blister films that permit permeation. The findings of the HCPC study support the longstanding theory that exposure to moisture and oxygen increases the risk of tablets' physical degradation, even under normal usage conditions. The results also showcase how the composition of tablet packaging can determine the medication's likelihood of degrading. Specifically, polypropylene vials, high-density polyethylene (HDPE) bottles and polyvinyl chloride (PVC) blisters, all of which are found in traditional retail and institutional pharmacy settings, may increase tablets' risk for higher physical degradation when compared to high-barrier single-dose packages such as PVC/AclarR or PVC/polyvinylidene chloride (PVdC) blisters.
Visit these innovative HCPC members!
|IMA Life North America Inc
|Korber Medipak Systems NA
|PCI Pharma Services
|Uhlmann Packaging Systems, LP
|Winpak Heat Seal Packaging Inc.
See you there!