Compliance Package of the Year Winners 2017

Healthcare Compliance Packaging Council (HCPC) Announces Compliance Packages of the Year

Richmond, Virginia – As part of its mission to improve patient adherence and outcomes through packaging and improve the safety of patients, the Healthcare Compliance Packaging Council (HCPC) is pleased to announce the winners of its annual Compliance Package of the Year competition. HCPC’s Compliance Package of the Year competition has been an annual event since 1995 and recognizes the most innovative pharmaceutical packages designed to improve patient adherence for the preceding market year, in this case 2017. This year two products’ packages, both developed to aid patients with metastatic breast cancer, tied for the Compliance Package of the Year. The winners are as follows:

Compliance Package of the Year: Novartis Kisqali® Dosepak® from Westrock-MPS

KISQALI® (ribociclib) is a solid dose prescription medicine used in combination with an aromatase inhibitor to treat pre/perimenopausal or postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer that has spread to other parts of the body (metastatic). Kisqali requires 3 pills a day to be taken at the same time, each day for 3 weeks and patient adherence to this regimen is extremely important.

The Kisqali® Medication Package promotes patient medication adherence using a custom design that integrates:

  • Calendared blister clearly labeled by day on each individual pill cavity, highlighting the one-week dosing regimen (3 one-week packages make up a monthly supply of Kisqali). Visual cues prompt medication taking and tracking for a three week on, one-week off dosing regimen
  • Heat-sealed inner card allows for multi-color graphics for easy to view calendar
  • Branding for Novartis / Kisqali on the outer package’s readable, flat space
  • When reviewing, one judge advised “The color-coordinated package provides graphic appeal and simple enough instructions. Pull-out tablet card and separate prescribing information/medication guide provide an appealing user experience, with easy-to-read type.”

2017 HCPC Compliance Package of the Year: Lilly Verzenio™ Dosepak

Lilly’s Verzenio (abemaciclib) is another solid dose drug approved for hormone receptor-positive, HER2-negative metastatic breast cancer. It requires the patient to take a morning and an evening dose.

The Verzenio™ Medication Package promotes patient medication adherence using a custom design that integrates:

  • Calendared blister clearly labeled by day on each individual pill cavity, highlighting the one-week dosing regimen (4 one-week packages make up a monthly supply of Verzenio). Visual cues prompt medication taking and tracking
  • 5/6th panel provides space for medication information, dosing instructions, and how to navigate the calendar
  • Branding for Lilly / Verzenio on the outer package’s readable, flat space

One of the judges reviewing the package stated, “Simplicity defines the Lilly Verzenio Dosepak. It opens without resistance. Instructions are remarkably clear. The package is easy to use, store and carry.”

“WestRock partnered with its customers to design packages to help metastatic breast cancer patients adhere to their medication,” said Dave Dwyer, VP, Global Marketing – Adherence, WestRock. Packaging is the one tool that stays with the patient throughout the medication journey, making it uniquely effective in providing regimen support.”

Both packages build on WestRock’s legacy of designing medication packaging that’s proven to enhance adherence. WestRock’s enhanced adherence packaging is shown to achieve an 80% PDC with up to 37% more patients versus standard vials.

2017 HCPC Compliance Package of the Year First Runner Up: Synergy Pharmaceuticals – Trulance

Submitted by PCI Pharma Services on behalf of Synergy Pharmaceuticals Inc., Trulance® (plecanatide) is a once-daily tablet approved in the U.S. for the treatment of adults with chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). Trulance is the only prescription medication for CIC and IBS-C available in a unique calendar pack that is patient preferred to a traditional pill bottle. The calendar pack is designed to help make it easy for patients to remember to take their medication. Trulance tablets are organized for each day of the week to ensure patients never miss a dose and the last two tablets of the 30-day pack are displayed with a reminder to refill the prescription. The Trulance package also utilizes the patented WestRock Dosepak which has proven to increase adherence, enabling and empowering patients to comply with complex regimens and ultimately driving refills.

2017 HCPC Compliance Package of the Year Second Runner Up: Merck PREVYMIS Dosepak

PREVYMIS is a prescription medicine to help to prevent cytomegalovirus (CMV) infection and disease in adults who have received an allogeneic hematopoietic stem cell (bone marrow) transplant. The PREVYMIS calendared blister wallet for the US market was designed to provide a comprehensive approach to initializing therapy utilizing a compliance promoting design.

This custom design utilizing WestRock’s Dosepak platform technology, integrates visual cues such as arrows to help guide each patient through daily dosing; encouraging compliance while keeping the dosing regimen simple to understand. The opening instructions are clearly illustrated with prominent text and differentiating colors.

The wallet provides ample space for medication information and dosing instructions in a very clear format to help patients. Branding and product description can be seen on the outer packaging and the package insert is contained within the 5th/6th panel.

One tablet must be taken daily and each wallet provides one week of therapy. Each blister cavity is individualized with the corresponding day of the week, permitting patients to start treatment any given day and indicating when they will finish the pack. Removing a tablet from the wallet provides visible evidence medication was taken that day. Additionally, it helps provide patients with a sense of accomplishment as they progress through the therapy and ensure the prevention of CMV.

The pack is both senior friendly and child resistant achieving an F=1 rating, as required for the US market. The blister cavities protect the product from moisture, oxygen and light.

One of the judges reviewing the Merck Prevymis compliance package commented, “Quite possibly the most patient-friendly instructions I’ve seen in a pharmaceutical compliance package! Large, legible typeface provides absolutely clear instructions: “HOW TO OPEN THIS PACKAGE” is a great example. So are the six steps on the top portion of the pack that show once the pack is opened. It’s as if Merck enlisted patients to actually write usage directions for this package, which may well have been the case. A job well done, especially given the investment in packaging materials for only seven tablets.”

The HCPC will present the awards for the 2017 and the upcoming 2018 Compliance Package of the Year awards at their March 2019 HCPC members meeting when the organization will host the IoPP Drug and Pharmaceutical Packaging Committee in Charleston, SC.

Previous compliance package of the year winners